Custom Peptides
Cayman Chemical Schzndrn 10mg
A lignan with diverse biological activities; induces cell cycle arrest at the G0/G1 phase and inhibits growth of T47D and MDA-MB-231 breast cancer cells at 100 μM; prevents glutamate-induced cytotoxicity, inhibits production of NO and ROS, and preserves the mitochondrial membrane potential in isolated rat cortical cells at 10 and 100 μM; reduces cisplatin-induced apoptosis in HK-2 cells; reverses scopolamine-induced impairment of spatial memory and the passive avoidance response in rats at 1 and 10 mg/kg; enhances oxotremorine-induced tremors in mice; reduces serum levels of IgE, IgG1, IL-4, and IFN-γ in an ovalbumin-sensitized mouse model of allergy at 10 mg/kg
Cayman Chemical VulpInIc AcId 10mg
A lichen metabolite with diverse biological activities; active against various bacteria (MICs = 4-16 μg/ml); prevents UVB-induced apoptosis, cytotoxicity, and cytoskeletal modifications in HaCaT human keratinocytes from 25-800 μM; increases scratch wound healing of HaCaT cells; reduces hydrogen peroxide-induced production of ROS and cytotoxicity in HUVECs at 15 μM
Cayman Chemical 3EthylethcathInonhydrochl 10mg
A substituted cathinone with potential for abuse; intended for forensic applications
Cayman Chemical ChenodeoxycholylputrescIn 10mg
A polyamine bile amidate; has been found in lion, but not mouse, fecal samples; has been used as a standard in the detection of chenodeoxycholyl-putrescine in mammalian intestinal and fecal samples
Cayman Chemical VU6036720hydrochlorIde 10mg
An inhibitor of heteromeric Kir4.1/5.1 channels (IC50 = 0.24 µM); selective for Kir4.1/5.1 channels over a variety of homomeric Kir channels, including Kir4.1 (IC50 = >10 µM), as well as heteromeric Kir3.1/3.2, Kir3.1/3.4, Kir6.2/SUR1, and Kir6.1/SUR2b channels at 30 µM but does inhibit the voltage-gated potassium channel Kv1.1 (IC50 = 6.4 µM); does not inhibit diuresis in mice at 30 and 100 mg/kg due to low oral bioavailability and high hepatic clearance
Cayman Chemical PyrIntegrIn 10mg
A 2,4-disubstituted pyrimidine that, at 2 µM, enhances the survival of hESC more than 30-fold after trypsin-mediated dissociation; increases integrin-dependent attachment of hESC to extracellular matrices
Cayman Chemical Nacetyl3 4MethylendIoxyme 10mg
An acetylated analog of methylone, the MDMA-type designer drug that has been detected in products marketed as bath salts, plant food, and tablets; intended for forensic and research purposes
Cayman Chemical AzasetronhydrochlorIde 10mg
An orally bioavailable 5-HT3 antagonist (Ki = 2.9 nM); selective for 5-HT3 over 5-HT1A and 5-HT2 (IC50 = >10 μM for both), as well as D1, D2, α1-, and α2-adrenergic receptors (IC50s = >10 μM); binds to H1 receptors (IC50 = 4.4 μM); inhibits 5-HT-induced contractions in isolated guinea pig ileum (pA2 = 7.04) and isolated rabbit heart (pA2 = 10.06); inhibits cisplatin-induced emesis in dogs and doxorubicin/cyclophosphamide-induced emesis in ferrets at 1 mg/kg
Cayman Chemical OxytocInacetate 10mg
A nonapeptide hormone primarily synthesized in the hypothalamus with roles in uterine contraction and lactation, social memory and attachment, sexual and maternal behavior, aggression, learning, anxiety, feeding, and pain perception
Cayman Chemical Agomelatn 10mg
A melatonin receptor agonist (Kis = 0.14 and 0.41 nM for MT1 and MT2, respectively) and 5-HT2B and 5-HT2C antagonist (Kis = 0.26 and 0.71 nM, respectively); inhibits the 5-HT2-mediated penile erection response in rats at 40 mg/kg; increases extracellular levels of noradrenaline and dopamine in the frontal cortex of freely moving rats at 20-80 mg/kg; reduces immobility time in the forced swim test and increases the amount of time spent in the open arms of the elevated plus maze in mice in a transgenic neuroendocrine model of depression at 10 mg/kg
Cayman Chemical TrequInsInhydrochlorIde 10mg
A cAMP-dependent PDE3 inhibitor (IC50s = 0.04 and 0.03 nM for PDE3A and PDE3B, respectively in T84 cell lysates); stimulates cAMP accumulation (10 µM) and increases membrane capacitance in rat juxtaglomerular cells; competitively inhibits multidrug resistant protein 5-mediated export of cGMP from Chinese hamster lung fibroblasts (Ki = 240 nM); reduces collagen-induced platelet aggregation in rabbits (3 UG/kg per minute); reduces collagen-induced decreases in mean arterial blood pressure alone or in combination with prostacyclin
Cayman Chemical 1MyrIstoyl2Oleoyl3Docosa 10mg
A triacylglycerol; has been used as a reagent to study the regioselectivity of thermal chlorination reactions between triacylglycerols and organochlorines that result in the formation of MCPD diesters
Cayman Chemical E6446hydrochlorIde 10mg
A TLR7 and TLR9 antagonist (IC50s = 1.78 and 0.01 µM, respectively); selective for TLR7 and TLR9 over TLR4 (IC50 = 10.58 µM); inhibits CpG ODN2216- or RNA40-induced IL-6 production in isolated mouse BMDCs; prevents increases in left ventricle chamber size and cardiac fibrosis in a mouse model of transverse aortic constriction-induced heart failure at 1.5 mg/animal; increases survival and reduces increases in right ventricular systolic pressure and hypertrophy in a rat model of monocrotaline-induced pulmonary hypertension at 10 mg/kg; has been used to enhance the transfection efficiency of cell-penetrating peptides for the delivery of mRNA in vitro